I am making my own case and wish to have the motherboard mounted with an angle 'forward' so that the motherboard would be hanging somewhat more than in the regular 90 degree mounting position.

But I have some worries about this causing strain on the motherboard, and how this may affect it on the long term (say 3-4 years of usage).

I won't be using a big cooling radiator, rather I will mount a water cooling block (which may or may not put more strain on it).

Does anyone have thoughts about this, is it something I can do without too much worrying or is it wiser to avoid such a construction?

Many thanks in advance.